摘要
目的:观察辛伐他汀联合心先安治疗冠心病左室舒张功能不全疗效。方法:60例确诊冠心病左室舒张功能不全患者随机分为两组,对照组采用常规方法治疗,治疗组在常规方法治疗的基础上加用心先安注射液120 mg加入5%葡萄糖注射液或生理盐水100 mL中静脉滴注,每日1次,同时予辛伐他汀20 mg每晚餐后服,每日1次。两组疗程均为3周。分别于治疗前和治疗后3周观察临床症状和体征及心功能测定,并行心脏超声心动图检查,测定每搏量、心排血量、心排血指数、左心室射血分数、室壁增厚率、左心室短轴缩短率等。结果:治疗3周后,治疗组患者心衰症状和体征、心功能明显改善,心排血量、每搏量、心排血指数、左心室射血分数、室壁增厚率、左心室短轴缩短率改善明显,与治疗前比较有显著性差异(P<0.05),其中每搏量、左心室射血分数与对照组亦有显著性差异(P<0.05);对照组以上指标治疗后虽有改善,但与治疗前比较无显著性差异(P>0.05)。结论:在常规方法治疗冠心病左室舒张功能不全的基础上联合应用辛伐他汀及心先安注射液,能有效地改善冠心病患者的左室舒张功能,从而改善患者的左心功能,提高运动耐量。
Objective： To study the effect of treating diastolic dysfunction of left ventricle with combining simvastatin and meglumine adenosine cyclophosphate. Methods： Sixty patients with confirmed diastolic dysfunction of left ventricle due to coronary artery atherosclerotic disease were divided randomly into trial group and control group. Patients in control group were treated using conventional therapy; patients in trial group were treated with meglumine adenosine cyclophosphate 120mg prepared with 5% GS or 0.9% NS infused intravenously once a day combined with simvastatin 20mg intaked orally after supper once a day on the base of conventional therapy. The therapeutic course was 3 weeks. Clinical symptoms, signs, heart function, strike volume, output volume per minute, cardiac index, ejection fraction of left ventricle, thicken ratio of systolic left ventricle, fraction of left ventricle shorten were observed and examined using echocardiography before and 3 weeks after the treatment respectively. Results： Of the patients in trial group 3 weeks after the therapy, symptoms and signs of heart failure, heart function strike volume, output volume per minute, cardiac index, ejection fraction of left ventricle, thicken ratio of systolic left ventricle, fraction of left ventricle shorten were all improved markedly; compared with those before therapy, there were significant differences （ P 〈 0.05 ） ; compared with those in control group after the therapy,there were significant differences（P 〈0.05）in strike volume, ejection fraction of left ventricle, and no significant differences（P〉0.05）in the rest though those had been improved. Conclusion： Patients with diastolic dysfunction of left ventricle treated with meglumine adenosine cyclophosphate and simvastatin on the base of conventional therapy may receive satisfactory effects of improving left ventricle diastolic function and systolic function, enhance exercise tolerance.
出处
《海南医学院学报》
CAS
2008年第3期233-235,共3页
Journal of Hainan Medical University
关键词
冠状动脉疾病
心室功能障碍
左
心舒期
药物疗法
联合
Coronary artery diseases
Ventricle dysfunction, left
Diastolic phase
Drug therapy, combination
