期刊文献+

辛伐他汀联用硝苯地平治疗老年舒张性心衰疗效分析

A clinical analysis of treating diastolic heart failure in the old people with simvastatin and nifedipine
暂未订购
导出
摘要 目的:探讨老年舒张性心衰患者采用辛伐他汀联用硝苯地平治疗的临床效果及应用。方法:随机在我院选择82例已明确诊断为舒张性心衰的老年患者,两组式随机分组,41例对照组患者采取的方法为常规药物联合硝苯地平治疗;41例研究组采取对照组联合辛伐他汀的方法,对照两组患者的心功能改善情况以及彩色多普勒超声测出的心室舒张早期(E)、晚期(A)最大血流速度并确定E/A值。结果:不同方法的疗效不同,研究组患者的有效率较对照组有效率高,且差异显著,具有明确意义,P<0.05;具有明确的心功能改善效果,心脏的射血分数可明显改善,研究组患者的E、E/A均有明显升高,A下降,与对照组相比更有优势。结论:辛伐他汀联用硝苯地平治疗老年人的舒张性心衰具有显著效果,可明显改善心功能,可在临床上推广。 Objective: To discuss clinical effects and application of simvastatin and nifedipine on treating diastolic heart failure in the old people. Methods: 82 patients were randomly divided into two groups, 41 cases for each. The control group was given conventional medicines plus nifedipine, the treatment was given simvastatin more. Improvement of cardiac function and maximum flow velocity in two groups were compared. Results: The total efficacy in the treatment was higher with significant difference, P〈0.05; E, E/A in the treatment was higher while A goes in counter way. Conclusion: Simvastatin and nifedipine has good effects on treating diastolic heart failure in the old people and can improve cardiac function, was worthy of further application.
作者 凌红日
出处 《中医临床研究》 2014年第13期135-136,共2页 Clinical Journal Of Chinese Medicine
关键词 辛伐他汀 硝苯地平 老年人 舒张性心衰 Simvastatin Nifedipine The old Diastolic heart failure
  • 相关文献

参考文献4

二级参考文献21

  • 1申丽婷,刘凤芹,刘新兰.氨氯地平治疗舒张性心力衰竭39例临床观察[J].山东医药,2006,46(13):48-48. 被引量:2
  • 2杨永超.辛伐他汀辅助治疗慢性心力衰竭60例疗效观察[J].中国基层医药,2007,14(3):465-466. 被引量:3
  • 3黄峻.慢性心力衰竭临床研究的新趋势[J].中华心血管病杂志,2007,35(7):593-594. 被引量:44
  • 4Greer JJ, Kakkar AK, Elrod JW,et at.Low-dose simvastatin improves survival and ventricular function via eNOS in congestive heart failure[J]. Am J Physiol Heart Circ Physiol, 2006,291 (6) : H2743.
  • 5Paulus WJ.Beneficial effects of nitric oxide on elimtiae diastolic function :the flip side of the coin[J].Heart Failure. Rev, 2000,5:337.
  • 6Gao L, Wang W, Li YL, et al. Simvastatin therapy normalizes sympathetic neural control in experimental heart failure: roles of angiotensin Ⅱ type 1 receptors and NAD(P)H oxidase[J].Circulation,2005, 112(12) : 1763.
  • 7Hong YJ ,Jeong MH, Hyun DW, et al.Prognostie significance of simvastatin therapy in patients with ischemie heart failure who underwent percutaneous coronary intervention for acute myocardial infarction[J].Am J Cardiol,2005,95(5):619.
  • 8Atkins CE, Rausch WP, Gardner SY,et al.The effect of amlodipine and the combination of amlodipine and enalapril on the renin-angiotensin-aldosterone system in the dog[J].J Vet Pharmacol Ther, 2007,30(5) : 394.
  • 9Mozafarian D, Minami E, Letterer R A, et al. The effect of atorvastatin( 10 nag)on systemic inflammation in heart failure. Am J Cardiol, 2005, 96(12): 1699.
  • 10Node K, Fujita M, Kitakaze M, el al. Short lerm statin therapy improves cardiac function and sympotms in patients with idiopathic dilated cardiomyopathy. Circulation, 2003, 108(7) : 839.

共引文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部