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蜂蛇胶囊对Beagle犬毒理学安全性评价

The Effect of Fengshe Capsule to the Toxicology and the Safe of Beagle
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摘要 蜂蛇胶囊为中药复方制剂,为了判断其对人体健康是否产生危害,本文进行了安全性毒理学评价.采用Beagle犬亚慢性毒性实验研究,实验数据判定,生理指标无异常改变,病理形态学改变为可逆性改变.结果表明蜂蛇胶囊对Beagle犬最小无毒剂量大于0.968g/kg/d,蜂蛇胶囊用于临床使用安全可靠. Fengshe capsule is a kind of compounded preparation of chinese traditional medicine. In order to estimate whether the medicine is harmful to human being, it was necessary to make the toxic assessment. Sub-chronic toxic experiment on Beagle was used. According to the result of the experiment, there was no significant change in physiology index and reversible change in pathology morphology was also observed. The minimum non-effect does on Beagle was more than 0.968 g/kg/d animal proved that it is safe , Experiment of animal proved that it is safe.
出处 《中央民族大学学报(自然科学版)》 2008年第2期68-70,77,共4页 Journal of Minzu University of China(Natural Sciences Edition)
基金 辽宁省科技攻关项目(No.2001225001-1)
关键词 蜂蛇胶囊 生理指标 病理形态学 可逆性改变 Fengshe capsule biologic index pathology morphology reversible change
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参考文献2

  • 1[2]卫生部药政局.新药(中药)临床研究指导原则汇编[M].中国医药科技出版社,2002.
  • 2郁仁存.1998国际中西医结合防治肿瘤学术研讨会纪要[J].中国中西医结合杂志,1999,19(2):7-9.

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