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针刺对缓慢性心律失常大鼠心肌Gi Gs含量影响 被引量:11

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摘要 目的:以蛋白印迹(Western blot)法测定电针治疗异搏定所致缓慢性心律失常大鼠心肌组织抑制性G蛋白(Gi)和激动性G蛋白(Gs)的含量,继而探讨针刺"内关"穴调节心律失常的效应机理。方法:用异搏定诱发大鼠缓慢性心律失常模型,成模后电针双侧"内关"穴。用MS2000多媒体生物信号记录分析系统记录心电图,观察针刺前后心率(律)变化;以蛋白印迹法测定大鼠心肌组织抑制性G蛋白(Gi)和激动性G蛋白(Gs)的含量。结果:电针治疗后,造模+针刺"内关"穴组大鼠的心率(律)以及大鼠心肌组织中Gi、Gs含量与正常对照组的心率(律)以及Gi、Gs含量对比发生明显改变(P<0.05)。结论:针刺"内关"穴能改善缓慢性心律失常;其作用机制与Gs蛋白的含量变化有关。
出处 《中华中医药学刊》 CAS 2008年第5期1014-1015,共2页 Chinese Archives of Traditional Chinese Medicine
基金 辽宁省教育厅资助项目(05L252)
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