摘要
目的用下体负压（ＬＢＮＰ）技术建立兔意识丧失（ＬＯＣ）的模型，旨在找出一些切实可行的ＬＯＣ监测指标。方法按阶梯下降的方法，将８只兔暴露于不同的负压值下（－１．３３ｋＰａ、－２．６７ｋＰａ、－４．００ｋＰａ、－５．３３ｋＰａ和－６．６７ｋＰａ），每种负压值持续作用１ｍｉｎ，观察兔发生ＬＯＣ的动态过程，并记录有关生理指标。结果ＬＢＮＰ可致兔发生ＬＯＣ、ＥＥＧ拉平，但滞后于颈总动脉血流量（ＣＢＦ）降到零后３９．７５±６．４０ｓ；ＣＢＦ与动脉血压的变化关系密切（ｒ＝０．９７１，Ｐ＜０．０１），其直线回归方程为Ｑ＝１．４０ＢＰ－４．７２（Ｑ为ＣＢＦ，Ｑ＝０时，ＢＰ＝３．３７ｋＰａ）。结论可选用ＣＢＦ降为零作为发生ＬＯＣ的监测指标；以ＥＥＧ拉平作为监测指标，会夸大ＬＯＣ的病理损害性；离心机实验时，眼水平动脉血压降为０ｋＰａ似乎可代替ＣＢＦ作为ＬＯＣ的监测指标。
Objective The purpose of this study was to find out feasible monitoring indexes for loss of consciousness (LOC). Methods Eight rabbits served as subjects. Their lower body were exposed to graded negative pressure environments (-1.33 kPa,-2.67 kPa,-4.00 kPa,-5 33 kPa,and -6 67 kPa) ,each grade lasted for 1 min. The dynamic course of LOC induced were observed, and related physiological parameters were recorded at the same time. Results Lower body negative pressure (LBNP) resulted in LOC and isoelectric EEG in all subjects and these changes took place 39.75±6.40 s after common carotid artery blood flow volume (CBF) dropped to 0 ml/min. A significant correlation ( r =0.97) was found between CBF and the mean arterial blood pressure (BP). The linear regression equation was Q=1.40 BP-4.72 (Q=0, BP=3.37 kPa). Conclusion CBF=0 can be used as a monitoring index for LOC. Using isoelectric EEG as monitoring index may exaggerate the pathological effect of LOC. Eye level BP droppd to 0 kPa may be used as the alternative of CFB for monitoring G LOC in centrifuge experiments.
出处
《中华航空航天医学杂志》
CSCD
1997年第3期167-171,共5页
Chinese Journal of Aerospace Medicine
关键词
负压
下体负压
意识丧失
兔
加速度
动物模型
Lower body negative pressure Loss of consciousness Rabbits Acceleration Animal model
