摘要
目的：研究蒙汉族间甲硝唑唾液药代动力学是否存在民族差异。方法：８名蒙古族健康志愿者（男５人，女３人）及８名汉族健康志愿者（男３人，女５人）单次口服甲硝唑０６ｇ。采用ＨＰＬＣ苦味酸内标法测定甲硝唑唾液浓度及３Ｐ８７软件计算药代动力学参数。结果：甲硝唑唾液浓度药时曲线符合一室开放模型，两组药时曲线近似。蒙古族组的Ｃｍａｘ（１０６０ｍｇ／Ｌ），Ｔｍａｘ（１８６ｈ）及ＡＵＣ（１９１３８ｍｇ／Ｌ·ｈ）与汉族组（分别为１１３２ｍｇ／Ｌ，１６０ｈ及１８５３８ｍｇ／Ｌ·ｈ）无显著差异（Ｐ＞００５）。蒙古族组的Ｔ１２ｋｅ（１０８０ｈ）虽较汉族组（９７３ｈ）稍长，但无统计学差异（Ｐ＞００５）。结论：甲硝唑唾液药代动力学在蒙汉族间无明显差异。
Objective: to study if racial difference in salivary pharmacokinetics of metronidazole(MTZ) between Mongolian and Han population exists? Method: Eitht Mongolian(5m and 3f) and eight Han (3m and 5f) healthy volunteers administered po a single dose of 06g metronidazole.Salivary metronidazole concentration was determined using HPLC method with picric acid as internal standard and the pharmacokinetic parameters were calculated using 3P87 program.Result: The time course of salivary metronidazole concentration fitted to a onecompartment open model and the MTZ salivary concentration time courses of two groups were similar.The Cmax(1060mg/L), Tmax(186h) and AUC(19138mg/L·h) in Mongolian group no difference with those in Han group (1132mg/L, 160h and 18538mg/L·h) (P>005).The T12ke of Mongolian group (1080h) was little longer than that of Han group (973h) but with no statistical significant difference of metronidazole salivary pharmacokinetics between these Mongolian and Han healthy volunteers.
出处
《内蒙古医学院学报》
1997年第3期13-15,共3页
Acta Academiae Medicinae Neimongol
基金
内蒙古自然科学基金
关键词
甲硝唑
唾液
药代动力学
metronidazole
saliva
pharmacokinetics
Mongolian population
Han population
