摘要
头颅创伤、脑卒中、脑肿瘤、缺血性脑损伤、出血性脑损伤均伴有脑水肿的发生,严重者可危及患者生命甚至造成死亡。水通道蛋白-4(Aquaporin-4)作为主要在脑组织中表达的水通道蛋白,起着调节脑内水转运的重要功能,参与脑水肿的病理生理过程,提示研究水通道蛋白-4表达水平可能为法医学外伤性脑损伤时间推断提供新的依据。
Trauma, stroke, brain tumor, ischemic brain injury and bleeding brain damage often associated with brain edema occurred. Patients who suffer those cases may endanger life or even died. Aquaporin-4, as a major expression of aquaporins in brain, plays an important role in regulating water transfer when brain edema. It is suggested that expression of aquparin- 4 may provide a new way to estimate the injury time of traumatic brain injury.
出处
《中国法医学杂志》
CSCD
2008年第2期101-103,共3页
Chinese Journal of Forensic Medicine
关键词
法医损伤学
水通道蛋白-4
创伤性颅脑损伤
脑水肿
血脑屏障
Forensic traumatology medicine
Aquaporin-4
Traumatic brain injury
Brain edema
Blood brain barrier
