TH1/TH2细胞因子与习惯性流产的关系研究被引量：13

The significance of the serum TH1/TH2 cytokine level in the recurrent spontaneous abortions

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摘要目的通过测定习惯性流产患者(RSA)及正常妊娠妇女外周血血清TH1/TH2细胞因子的含量,探讨TH1/TH2细胞因子与习惯性流产发生的关系。方法采用酶联免疫吸附法检测30例RSA患者,72例正常妊娠妇女血清IL-2、IL-4、IL-10、IFN-γ、TNF-α及TNF-β水平并比较两组之间的差异。结果RSA患者IL-2、IL-4、IL-10、IFN-γ、TNF-α血清水平显著高于正常妊娠妇女(P<0.05),TNF-β血清水平显著低于正常妊娠妇女(P<0.05)。结论血清IL-2、IL-4、IL-10、IFN-γ、TNF-α水平可能在习惯性流产发生中起重要作用。 Objective：To investigate the significance of serum Th1 and Th2 cytokine profiles in in the recurrent spontaneous abortions.Methods：Cytokines including IL-1,IL-2,IL-4,IL-10,IFN-γ,TNF-α,TNF-β in serums obtained from 30 RSA and 72 normal pregnant women were analyzed with enzyme-linked immunosorbent assay（ELISA） method,and its significnace was analyzed between the two groups.Results：the serum IL-2,IL-4,IL-10,IFN-γ,TNF-α level was markedly higher in the RSA group than that in normal groups（P〈0.05）,while the TNF-β was significantly lower in the RSA groups（P〈0.05）.Conclusion：Level of the IL-2,IL-4,IL-10,IFN-γ,TNF-α in serum could play a critical role in the pathogenesis of the RSA.

作者尚定昆郑晓群颜卫华金志燕刘辛妍徐秀萍张巨香

机构地区乐清市第二人民医院检验科温州医学院附属第二医院检验科浙江省台州医院中心实验室乐清市妇幼保健院妇科

出处《中国优生与遗传杂志》 2008年第4期25-26,共2页 Chinese Journal of Birth Health & Heredity

基金浙江省乐清市科技计划项目资助(2006Y018)

关键词习惯性流产细胞因子 TH1/TH2 Spontaneous abortions Cytokine TH1/TH2

分类号 R714.2 [医药卫生—妇产科学]

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