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骨关节炎研究与基因芯片技术 被引量：2

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摘要 骨关节炎(OA)是一组具有不同病因而有相似的生物力学、形态学和临床表现的疾病,有着多种致病基因。基因芯片技术是多基因病研究的有力工具,但应用于OA研究只有短短8年,旨在一是发现一批新的致病基因(如几丁质酶样3蛋白2、几丁质酶样3蛋白1、丛生蛋白等,几丁质胶原参与软骨组织,其网架可构建组织工程化软骨;丛生蛋白是一种分泌型异二聚体糖蛋白,在多种恶性肿瘤细胞中表达都有升高,是细胞死亡的标志),二是阐明已知致病基因白介素-1β(Il-1β)、骨形态发生蛋白的基因作用网络,如在细胞中发现转化生长因子-β可通过其激活性激酶1来下调Il-1β表达。该文就基因芯片技术概念、原理、流程、目前应用于OA研究的状况作一综述。
作者 陈刚 徐卫东
机构地区 长海医院骨科
出处 《国际骨科学杂志》 2008年第2期78-80,共3页 International Journal of Orthopaedics
关键词 骨关节炎 基因芯片 基因组学
分类号 R684.3 [医药卫生—骨科学]
  • 相关文献

参考文献30

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二级参考文献58

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共引文献127

同被引文献17

  • 1刘爱华,陈颖娟,王钱,黄慈波.骨关节炎中软骨细胞的CD80/CD86的表达及白细胞介素18对其影响[J].中国临床保健杂志,2006,9(2):103-105. 被引量：4
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  • 8蒋青,翁文杰,陈东阳,徐志宏,邱旭升.高度屈曲畸形膝的全膝关节置换策略[J].中华骨科杂志,2009,29(5):476-479. 被引量：10
  • 9骨关节炎诊断及治疗指南[J].中华风湿病学杂志,2010,14(6):416-419. 被引量：1429
  • 10甘煜东,徐达传,陆声,丁晶,徐永清.数字化导航模板辅助全膝关节置换的模拟研究[J].中华骨科杂志,2011,31(9):964-969. 被引量：17

引证文献2

二级引证文献7

国际骨科学杂志
2008年 第2期

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