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同型半胱氨酸水平与脑梗死及动脉狭窄支数的相关性研究 被引量:5

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摘要 目的探讨同型半胱氨酸(Hcy)水平与脑梗死以及动脉狭窄支数的关系。方法选择80例脑梗死患者(脑梗死组)与50例对照者(对照组)。脑梗死组患者中,磁共振成像血管造影(MRA)检查有≥2支动脉狭窄者32例,设为A组,无或有1支动脉狭窄者48例,设为B组。采用高效液相色谱分析法测定各组血浆Hcy水平,同时测定血清叶酸、维生素B12(VitB12)、血脂、血糖等指标。结果脑梗死组Hcy水平[(21.10±8.98)μmol/L]显著高于对照组[(12.494±7.43)μmol/L,P〈0.05],叶酸、VitB12水平低于对照组,差异均有统计学意义。A组Hcy水平[(24.65±11.20)μmol/L]显著高于B组[(18.79±9.97)μmol/L,P〈0.05],A组叶酸水平[(3.63±2.32)μg/L]明显低于B组[(4.82±2.26)μg/L,P〈0.05]。VitB12水平A组低于B组,但差异无统计学意义。结论高同型半胱氨酸血症是脑梗死的重要独立危险因素,Hcy水平升高与脑梗死及动脉狭窄支数有关。
出处 《中国医师进修杂志(内科版)》 2008年第4期50-51,共2页 Chinese Journal of Postgraduates of Medicine
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参考文献4

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  • 2李保华,毛利忠,王克义,雷志锴,牛国忠.脑梗死与高同型半胱氨酸血症的相关性研究[J].中国实用神经疾病杂志,2006,9(1):8-10. 被引量:97
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