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5-脂氧合酶与细胞增殖及凋亡 被引量：1

5-Lipoxygenase and Cell Proliferation and Apoptosis
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摘要 5-脂氧合酶是5-脂氧合酶代谢通路中催化花生四烯酸转化为白三烯和氢氧化物的关键酶,在恶性肿瘤和多种病变细胞中高表达。它可以通过分裂原活化蛋白激酶激酶/细胞外信号调节激酶以及磷酯酰肌醇3激酶/蛋白激酶B等信号转导途径促进肿瘤细胞增殖,抑制肿瘤细胞凋亡。除此之外,5-脂氧合酶还可通过多种方式调控呼吸系统、消化系统以及循环系统等病变细胞的增殖与凋亡。 5-Lipoxygenase is the key enzyme that catalyze arachidonic acid into leukotriene and hydroxide in 5-lipoxygenase metabolic pathway.The expression of 5-lipoxygenase was obviously elevated in the cells of malignant tumours and other diseases.5-Lipoxygenase can promote cell proliferation and inhibit apoptosis by MEK/ERK,PI3K/Akt and other signal transduction pathways.In addition,5-lipoxygenase regulates cell proliferation and apoptosis in many kinds of disease,for instance,systema respiratorium,digestive system and Circulatory system.
作者 雷军荣 石松生 杨卫忠
机构地区 福建医科大学附属协和医院神经外科
出处 《医学综述》 2008年第6期826-828,共3页 Medical Recapitulate
关键词 肿瘤 花生四烯酸盐5-脂氧合酶 细胞增殖 细胞凋亡 Tumor 5-Lipoxygenase of arachidonate Cell proliferation Apoptosis
分类号 R730.23 [医药卫生—肿瘤] R329.2 [医药卫生—人体解剖和组织胚胎学]
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参考文献20

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同被引文献11

  • 1王磊,陈卫昌,杨吉成.环氧合酶-2小分子干扰RNA对人结肠癌细胞增殖和凋亡的影响[J].苏州大学学报（医学版）,2008,28(1):16-19. 被引量：3
  • 2李勇,李建英,王小众.5-脂氧合酶促癌机制研究进展[J].世界华人消化杂志,2006,14(8):800-804. 被引量：4
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  • 6Gadalla MM, Snyder SH. Hydrogen sulfide as a gasotransmitter[J]. J Neuroehem, 2010,113( 1 ):14 -26.
  • 7Pupo E, Pla AF, Avanzato D, et al. Hydrogen sulfide promotes calcium signals and migration in tumor derived endothelial cells[J]. Free Radic Biol Med, 2011,51 (9):1765-1773.
  • 8Hayasaka A, Suzuki N, Fujimoto N, et al. Elevated plasma levels of matrix metalloproteinase type IV conagenase/ gelatinaseB) in hepatocellular carcinoma[J]. Hepatology, 1996,24(5):1058-1062.
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医学综述
2008年 第6期

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