摘要
谷胱甘肽是细胞内重要的抗氧化损伤物质之一．以NADH诱导的牛心肌线粒体脂质过氧化体系为模型，研究了谷胱甘肽的抗氧化作用．结果表明，一定浓度的谷胱甘肽能够部分抑制该体系中线粒体的脂质过氧化．保护组的丙二醛含量为损伤组72．5％；线粒体的膨胀度较损伤组降低；细胞色素C氧化酶及ATP酶活力分别较损伤组提高了1．5及2．2倍．
Glutathione is believed to be very important in cellular defense against lipid peroxidation. Its effect on NADH-induced mitochondria lipid peroxidation system has been examined. The results showed that at certain concentration, GSH could partly prevent mitochondria from the damage of lipidperoxidation. Adding 10 μmol/L GSH to the injury system,the contents of malondialdehyde (MDA) was 72. 5% of that of the injury group;swelling of mitochondria decreased;membrane fluidity increased;activities of cytochrome c oxidase and ATPase of mitochndria were 1.5-fold and 2. 2-fold respectively of that in the injury group.
出处
《生物化学杂志》
CAS
CSCD
1997年第3期287-291,共5页
基金
酶工程国家重点实验室开放基金!95010
关键词
线粒体
过氧化脂质
谷胱甘肽
Mitochondrion, Lipid peroxidation, Glutathione
