摘要
用ＲＴＰＣＲ方法，定量检测了３０例食管癌和相应切断正常粘膜组织中多药抗药（ＭｕｌｔｉＤｒｕｇＲｅｓｉｓｔａｎｃｅ，ＭＤＲ）性基因１的表达。结果：癌组织中３３．３％的病例存在ＭＤＲ１基因的表达，而相对应的切断正常粘膜组织中，仅有１３．３％的病例存在ＭＤＲ１基因的表达，皆为低中度表达。Ｐ＜０．０５，２者间差异有显著性。但ＭＤＲ１基因的表达与食管癌临床病理资料如性别、年龄、肿瘤大小、分级、淋巴结转移、ＴＮＭ分期等无关。结果提示：ＭＤＲ１基因的表达在食管癌的发生中起一定的作用，它可能与食管癌的原发性耐药有关。
Expression of MDR1 gene was detected quantitatively with reverse transcription polymerase chain reaction in the cancerous tissues and corresponding normal mucosa from 30 patients with primary esophageal carcinoma.The results showed that in 33.3%(10/30) of the cancerous tissues and 13.3%(4/30) of the normal mucosa the expression of MDR1 gene were observed,and the comprison was of significant defference( P <0.05).However the expression of MDR l gene wasn’t related to the clinical and pathological data such as sex,age,the size of tumor,the degree of differentiation,metastasis of lymph node,the stage of TNM etc.It is suggested that the expression of MDR1 gene play a certain role in development of esophageal carcinoma and might be associated with the primary multidrug resistance of esophageal carcinoma.
出处
《河南医科大学学报》
1997年第3期15-18,共4页
Journal of Henan Medical University
基金
国家"八五"科技攻关项目
河南省重大科技攻关项目
