摘要
为探讨新生儿在缺氧缺血性脑病（ＨＩＥ）状态下肾脏的病理及功能损害，采用新生猪制作缺氧缺血性脑病模型。结果发现新生猪经２小时缺氧缺血后，在脑组织出现类似新生儿ＨＩＥ病理损害的同时，肾脏出现肿胀，包膜下出血，肾小管上皮细胞肿胀，管腔变窄，少数上皮细胞坏死脱落，肾小管基膜完整，血清尿素氮及肌酐明显升高（Ｐ＜０．０２５及Ｐ＜０．０５），表明在ＨＩＥ状态下新生猪已出现肾脏的病理及功能损害，但损害程度较轻，解除缺氧７２小时后，上述损害基本恢复正常。
To study the kidney lesions complicated by hypoxic ischemic encephalopathy (HIE) in newborn,we successfully established a neonatal pig model of HIE. Changes in brain tissue similar to those of newborn in HIE were detected after 2 hours of hypoxia and ischemia.Meanwhile,swelling of kidneys,hemorrhage below encapsules,swellin of tubular epithelial cells,necrosing and falling of a few tubular epithelial cells,and narrowing of tubular lumens were observed.The basement membranes of renal tubules remained normal serum BUN and creatinine increased significantly after experiment compared with before( P <0 025 and P <0 05 respectively).The results showed that the kidney of neonatal pig was damaged in HIE.But the injury was not severe.After 72 hours free from hypoxia,the structure and function recovered approximately from the injury.
出处
《华西医科大学学报》
CSCD
1997年第2期201-203,共3页
Journal of West China University of Medical Sciences
