摘要
目的探讨以尿α1微球蛋白(α1M)作为评价新生儿缺氧缺血性脑病(HIE)患儿肾功能损害指标的价值及尿α1M的水平与脑组织损伤程度之间的关系。方法设研究组37例HIE患儿及对照组9名正常足月儿,采用酶联免疫吸附法(ELISA)及全自动生化分析仪检测新生儿第2～3天的血清中的α1M、血尿素氮、血肌酐及尿α1M的浓度,结合相关临床资料对比分析,并进行统计学处理。结果新生儿HIE组尿α1M明显高于正常对照组(P<0.05);轻度、中度、重度HIE患儿尿α1M相互之间进行比较,结果提示轻度与中度、重度HIE患儿尿α1M差异均存在统计学意义(P<0.05);中度、重度HIE患儿尿α1M之间差异无统计学意义(P>0.05);轻度HIE患儿与正常足月儿之间尿α1M差异无统计学意义(P>0.05)。经相关分析,尿α1M与HIE患儿的轻重程度存在相关性,r=0.556,P<0.01。HIE患儿三组间血清α1M差异无统计学意义(P>0.05)。结论尿α1M的测定可以早期判定HIE患儿的肾功能损伤;尿α1M与HIE的分度呈正相关,对协助临床分度、指导治疗及估计预后有一定价值。
Objective To probe into urine level of α14-microgldmlin as an evaluation index to the renal function impairment of newborns with hypoxic-ischmaic encephalopathy （HIE） ,and its relationship to the injury degree of brain tissue. Methods α1-Microglobulin in senam,blood urea nitrogen,blood creatinine and α1-microglobulin in urine of HIE（37） and normal control （9） were measured with enzyme-linked inmatlnosorbent asseay and whole automatic biochemistry analyzer, dealing with some data by means of statistic method. Results The urine level of α1-microglobulin in HIE was significantly higher than that in normal control （P〈0.05）.Among different stages of HIE, the urine level of α1microglobulin of infants with stage 2 or stage 3 was significantly higher than that with stage 1 （P〈0.05）. The difference of urine levels of α1-microglobulin between stage 2 and stage 3 was not significant （P〉0.05）.At the same time the difference of urine level of α1-microglobulin between stage 1 and normal control was not significant （P 〉 0.05）. Through correlation analysis, the urine level of α1-microglobulin was assodated with the stage of HIE （P〈 0.01, r =0.556）. At different stages of HIE,the difference of the serum levels of α1-microglobutin was not significant. Conclusion Urine level of α1-microglobulin may be uese for evaluating the renal function; it has positive corrdation with the stage of HIE, therefore it may have great value on earlier assessing the stage of HIE, instructing the treatrnent and appraising the prognosis.
出处
《山西医药杂志》
CAS
2005年第9期722-724,共3页
Shanxi Medical Journal
