摘要
本实验将碱性成纤维细胞生长因子（ｂＦＧＦ）应用于大鼠任意皮瓣，观察ｂＦＧＦ对缺血皮瓣的坏死率、皮瓣局部组织中超氧化物歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）和一氧化氮（ＮＯ）含量的影响，初步探讨ｂＦＧＦ对皮瓣存活的作用机制。结果显示：ｂＦＧＦ治疗组与肝素盐水组比较：（１）皮瓣坏死率明显降低，皮瓣下肉芽组织层明显增厚，毛细血管和成纤维细胞明显增多；（２）中、远段皮瓣中ＳＯＤ含量在术后２４ｈ、４８ｈ明显升高；（３）中、远段皮瓣中ＭＤＡ含量在２４和４８ｈ明显低于对照组；（４）中、远段皮瓣中ＮＯ含量在术后２４ｈ、４８和９６ｈ均明显低于对照组。结果提示局部应用ｂＦＧＦ能有效降低缺血皮瓣的坏死率，促进局部组织ＳＯＤ水平的升高，降低自由基水平。ｂＦＧＦ有可能在皮瓣缺血的防治方面具有一定的作用。
An animal model of caudally based random skin flap was established in 54 Wistar rats to observe the effects of bFGF on skin flap survial, SOD, MDA and NO in skin flap tissues. The results showed that in bFGF treated group, flap necrosis was significantly lower, MDA and NO reduced significantly, and SOD elevated at the middle and distal parts as compared with those in the control group. These findings suggest that bFGF treatment may result in an improvement of the ischemic flap survival and an alleviation of the lipid peroxidation.
出处
《军医进修学院学报》
CAS
1997年第2期125-127,共3页
Academic Journal of Pla Postgraduate Medical School
基金
国家自然科学基金
