摘要
以胸苷为原料，先用甲磺酰氯将３′，５′－羟基保护制得化合物（２），然后在氢氧化钠水溶液中形成３′，５′－Ｏ－环状物（３），再与叔丁醇钾作用生成２′，３′－二脱氧－２′，３′－二脱氢胸苷（４），最后通过Ｐｄ－Ｃ加氢得到２′，３′－二脱氧胸苷（５），总收率为３３．６％．
The 2′,3′ dideoxythymidine posseses antiviral activity.From 2′ deoxythymidine,3′,5′ di O mesylthymidine(2) was prepared in 86 3% yield,which in treatment with NaOH in H 2O gave 67 4%(3),then treated with KOBu tert in DMSO to give 90%(4).Finally,(4) reacted with H 2 to yield 64 1%(5).The total yield of (5) was 33 6%.
出处
《中国药物化学杂志》
CAS
CSCD
1997年第3期208-209,共2页
Chinese Journal of Medicinal Chemistry
