摘要
目的回顾性分析镰孢菌感染所致的真菌性角膜炎共焦显微镜影像特征及疗效。方法将43例(43眼)临床确诊的镰孢菌感染所致的真菌性角膜炎进行裂隙灯显微镜及共焦显微镜检查,并详细记录。结果43例镰孢菌感染所致的真菌性角膜炎裂隙灯显微镜观察:23例(92%)可见菌丝苔被,20例(80%)可见羽毛状浸润边缘,8例(18·6%)观察到前房积脓;共焦显微镜下显示:19例(44·2%)上皮层及浅基质层检查到长度50～200μm,直径2～5μm的树枝状菌丝;16例(37·2%)显示浅中基质层的杂乱分布的直、长线状菌丝,直径3～7μm,长度150～300μm。结论菌丝苔被、羽毛状浸润边缘是镰孢菌属感染所致的真菌性角膜炎的主要临床特点。不同菌种镰孢菌属感染所致的真菌性角膜炎的共焦显微镜影像表现较为一致,可见典型的菌丝形态。
Objective Keratomycosis is a suppurative, usually ulcerative corneal disease. Members of the filamentous fungal genus Fusarium are the most frequently cause of the ketatomycosis in humans, This study was to characterize restrospectively the clinical features and confocal microscopic imaging features of Fusarium keratitis. Methods Forty-three cases with Fusarium keratitis determined by fungal cultured were reviewed. Results Of the 43 patients analyzed in this study, 19（44. 2% ） were male,and 24（55.8% ） were female. The average age of patients was 44.9 ± 12.4 years. The tough elevated surface was seen in the cornea under the slit lamp biomicroscope in 23 of 43 patients. The feathery border appeared in 20 patients. The bright hyper-reflective branching structures were revealed under the confocal microscope, and the hypha ranged 2 -5 μm in diameter and 50 -200μm in length in 19 patients. In 16 eyes, bright hyper-refleetive line structures appeared under the confocal microscope,and the hypha ranged 3 to 7 μm in diameter and 150 -300μm in length. Conclusion The tough elevated surface and feathery border are believed to be the primary clinical features of keratitis infected by Fusarium. The hypha present two kinds of configuration in Fusarium keratitis. The keratitis caused by Fusarium has the similar imaging characteristics
出处
《眼科研究》
CAS
CSCD
北大核心
2008年第3期219-221,共3页
Chinese Ophthalmic Research
基金
河南省科委科技攻关项目(971200253,0224630071)
