摘要
采用6Gy 照射复合15%Ⅲ度烧伤模型,探讨 SD-Zn 或 SD-Ag 涂抹创面与切痂植皮时机对复合伤大鼠的疗效作用。结果表明伤后 SD-Zn 或 SD-Ag 涂抹创面并于15天后切痂植皮及单用 SD-Zn涂抹组,伤后15天存活率分别为63%、69%和75%,均高于对照组(42%);创面面积缩小速度明显加快,血细胞数也低于对照。用 SD-Zn 涂抹后7天植皮组,术后20天内动物全部死亡,而15天后植皮者术后动物全部存活。提示:SD-Zn 或 SD-Ag 涂抹对复合伤创面有较好疗效,而放射伤极期应禁做手术治疗,若恢复期机体状况较好者可进行切痂植皮。
Effects of local use of sulfadiazine (SD) zinc,SD silver in the wound and skin transplan- tation on the combined injury of 6 Gy radiation and 15% TBSA burn were investigated in the present study.In the three groups of SD zinc or SD silver plus skin grafting at 15 d after combined injury and SD zinc alone,the 15-day survival rates were 63%,69% and 75% respectively,and significantly higher than that of control group (42%).The repair time of burn wound was shorter and the number of white blood cells was lower than that of control.Animals in the group of local use of SD silver followed by skin grafting on the 7th day all died,but all of the animals survived when the skin grafting was per- formed after 15 days.These results suggested that SD zinc and SD silver showed some therapeutic ef- fects on the combined radiation-burn injury.In critical phase of the combined injury,surgical operation should be prohibited.However,in the recovery phase,skin transplantation could be performed.
关键词
放烧复合伤
切痂植皮
磺胺嘧啶锌
磺胺嘧啶银
Combined radiaion-burn injury
Sulfadiazine zinc
Sulfadiazine silver
Skin grafting
