摘要
载脂蛋白D(apolipoprotein D,apoD)是一个29kDa的糖蛋白,它最初是在人血浆的高密度脂蛋白中被分离出来的。apoD在结构上与其他类型的载脂蛋白存在很大的差异,被归入脂肪促成素家族。apoD可以与胆固醇、黄体酮、胆红素等多种疏水性小分子结合。另外,apoD在多种脊索动物的各类组织中广泛表达,揭示了apoD在脊椎动物中重要的生理功能。最近的研究表明,apoD可以作为多种癌症及神经系统疾病的早期诊断标记,因而备受关注。所有这些显示apoD是一个多配体、多功能的蛋白质。
Apolipoprotein D （apoD） is a 29-kDa glycoprotein that was initially isolated from human plasma high density lipoproteins fraction. It is an atypical apolipoprotein and was subsequently identified to be a member of lipocalin family by structural analysis. Several small hydrophobic molecules were identified as potential ligand for apoD, such as cholesterol, progesterone and bilirubin. Wide distribution of the apoD gene in the tissues of several chordates suggests the functional importance of its corresponding protein. Recently study reveals that ApoD has received attention as prognostic marker for various cancer development and neurological diseases. All of these indicate that apoD is likely to be a multi-ligand, multi-functional protein.
出处
《细胞生物学杂志》
CSCD
2008年第1期50-54,共5页
Chinese Journal of Cell Biology
基金
国家自然科学基金(No.30740017)
鲁东大学校科研基金(No.20063301)资助项目~~
关键词
载脂蛋白D
结构
功能
临床应用
apolipoprotein D
structure
function
clinical application
