摘要
目的:探讨激素性股骨头坏死(ANFH)的病理发展过程及影像学表现。方法:将30只家兔随机分为模型组、对照组,用氢化可的松制成激素性股骨头缺血性坏死模型,分别观察注射后2、4、6、8、10周股骨头组织病理学和影像学改变。结果:组织病理学观察:模型组早期变化较局限,8周以后股骨头骨细胞变性、坏死,空缺骨陷窝增多,骨小梁变细、断裂,结构紊乱;对照组正常。钼靶X线摄影兔股骨头可见斑片状密度减低影;CT兔股骨头可见囊状透亮区和斑片状密度减低影;MRI兔股骨头在T1WI呈不规则低信号,T2WI呈低信号或高信号。结论:氢化可的松能成功制作家兔股骨头缺血性坏死模型,而且改进方法效果更理想;早期股骨头缺血性坏死影像诊断上CT和MRI优于钼靶X线,MRI是诊断最敏感的方法。
Objective： To study the pathological progression and early imaging diagnosis of steroid-induced avascular necrosis of femoral head.Methods：30 rabbits were randomly divided into model and control groups after finishing the models of hormone induced necrosis of femoral head. The rabbits were killed 2,4,6,8,10 weeks after carrying out each kind of examination separately, including histopathological,imaging and electron microscopic changes. Results：Histopathological changes： the model group there is small change early and after 8 weeks, empty osteocyte lacuna increased and trabecula of bone decreased, ruptured are all observed. The control group are normal. Molybdenum target X-ray： in group model, the density of the bone is non-uniform decreased; CT scanning： in group model the pathological changes are aggravated, the density is obviously decreased, the bone trabeculae transparent areas are found. In group model the change of MRI, T1WI showed the non- uniform low signal, T2WI intermediate or high signal. Conclusion：The models of avascular necrosis of femoral head can be made in hydrocortisone. CT and MR are superior to molybdenum target X-ray in the early diagnosis of the necrosis of femoral head. MRI is the most sensitive approach.
出处
《医学影像学杂志》
2008年第2期183-186,共4页
Journal of Medical Imaging
关键词
股骨头坏死
激素
动物实验
影像学
Femoral head necrosis
Hormone
Animal experimenal
Imaging
