摘要
背景与目的:非小细胞肺癌(non-small cell lung cancer,NSCLC)的多学科治疗已有十多年,诊断技术及治疗策略的改进有可能导致NSCLC的预后影响因素的改变。本文探讨NSCLC完全切除术后的预后影响因素。方法:收集1997年1月～2001年4月行完全切除术的899例NSCLC病例资料及随访资料,采用Kaplan-Meier进行生存分析,Cox模型进行多因素生存分析。结果:全组5年生存率为43.5%,中位生存期48个月。其中ⅠA期、ⅠB期、ⅡA期、ⅡB期、ⅢA期、ⅢB期、Ⅳ期的5年生存率分别为81.0%、60.3%、56.9%、45.7%、23.5%、20.8%、13.0%;单因素分析显示T分期、N分期、M分期、组织学类型、组织分化、腺癌Ⅱ期及Ⅳ期化疗、腺癌N2期术后纵隔放疗为预后影响因素;多因素分析显示组织学类型、T分期、N分期、M分期及腺癌N2期术后纵隔放疗是NSCLC独立预后因素。结论:除T分期、N分期、M分期外,组织学类型及腺癌N2期术后纵隔放疗也是完全切除NSCLC的独立预后因素。
BACKGROUND ＆ OBJECTIVE： Multi-displinary management for non-small cell lung cancer （NSCLC） has been applied for more than ten years. The progresses in the diagnosis and management of NSCLC might change the factors affecting prognosis. This study was to explore the prognostic factors of NSCLC after complete resection. METHODS： Clinical data of 899 NSCLC patients, underwent complete resection from Jan. 1997 to Apr. 2001 at Cancer Center of Sun Yat-sen University, were reviewed. The patients were followed up till 31st Mar. 2006. Survival rates were calculated by Kaplan-Meier method. The prognosis was analyzed by Cox proportional hazards model. RESULTS： The 5-year survival rate of the 899 patients was 43.5% and the median survival time was 48 months. The 5-year survival rates were 81.0% for the patients at stage Ⅰ A, 60.3% for stage Ⅰ B, 56.9% for stage Ⅱ A, 45.7% for stage Ⅱ B, 23.5% for stage Ⅲ A, 20.8% for stage Ⅲ B, and 13.0% for stage Ⅳ. Univariate analysis showed that T stage, N stage, M stage, histological type, differentiation, chemotherapy for adenocarcinoma （ADC） at stages Ⅱ and Ⅳ, and mediastinal radiotherapy for ADC at stage N2 were prognostic factors. Multivariate analyses showed that histological type, T stage, N stage, M stage and mediastinal radiotherapy for ADC at stage N2 were independent prognostic factors. CONCLUSION. Besides T stage, N stage, and M stage, histological type and mediastinal radiotherapy for ADC at stage N2 are also independent prognostic factors of NSCLC after complete resection.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2007年第11期1231-1236,共6页
Chinese Journal of Cancer
关键词
肺肿瘤
癌
非小细胞
完全切除术
多因素分析
预后
Lung neoplasm
Carcinoma, non-small cell
Complete resection
Multivariate analysis
Prognosis
