摘要
1-(2,3-二氯苯基)哌嗪盐酸盐是重要的医药中间体。以二乙醇胺为起始原料,经氯代反应制得β,β'-二氯代二乙基胺盐酸盐,然后在水溶液中不使用催化剂条件下与2,3-二氯苯胺经环合反应合成目标化合物1-(2,3-二氯苯基)哌嗪盐酸盐。产物结构经红外光谱、核磁共振氢谱分析验证与目标化合物的结构一致。该方法经济环保,简单易操作。
1-（2,3-Dichlorophenyl）piperazine hydrochloride is an important pharmaceutical intermediate. The starting material diethanolamine was halogenated to giveβ,β＇-dihalogenated diethyiammonium hydrochloride, and then reacted with 2,3-dichloroaniline in aqueous solution without any catalyst to afford the target compound piperazine hydrochloride. The product was characterized by ^1H NMR and IR spectroscopy whic proposed structures. 1-（2,3--dichlorophenyl） h was consistent with the
出处
《精细化工中间体》
CAS
2008年第1期18-21,共4页
Fine Chemical Intermediates
基金
江苏工业学院科技基金(ZMF05020022)
