摘要
用大鼠动静脉血栓形成模型，研究参三七皂甙Ｒｇ１抗血栓作用。结果表明，参三七皂甙Ｒｇ１可明显降低实验性血栓形成，对大鼠血浆纤溶系统亦有明显作用，可升高血浆中组织纤溶酶原激活物（ｔＰＡ）活性和活性型ｔＰＡ百分比，降低组织纤溶酶原激活物抑制剂（ＰＡＩ）活性。同时利用培养大鼠血管内皮细胞实验，发现Ｒｇ１可以剂量依赖性提高血管内皮细胞一氧化氮（ＮＯ）释放。提示Ｒｇ１抗血栓作用与增强纤溶系统活性。
The effect of sanchinoside Rg 1 on generation of thrombosis and its mechanism was studied. Rg 1 was shown to markedly inhibit experimental thrombosis formation induced by extra corporeal shunt between the carotid artery and jugular vein. After Rg 1 infusion, the activity of t PA was found to be increased, so did the percentage of active type t PA, but the activity of PA I decreased. Further data in our study indicate that incubation of endothelial cells with Rg 1 for 24 h caused significant increase of NO production. This effect was found to be dose dependent. These observations suggest that Rg 1 is a potent anti thrombosis substance and can enhance the function of fibrinolysis system and stimulate vascular endothelial cells to release NO.
出处
《药学学报》
CAS
CSCD
北大核心
1997年第7期502-506,共5页
Acta Pharmaceutica Sinica
关键词
参三七皂甙
血栓形成
药理
Sanchinoside Rg 1
Thombosis
Tissue plasminogen activator
Plasminogen activator inhibitor
Nitric oxide
