摘要
采用血液流变学及应力波理论,对高速螺旋血泵中血液撞击损伤机理进行研究,分析红细胞-固壁撞击破碎的过程和红细胞膜冲击破碎的条件;通过血液撞击损伤实验,对不同撞击速度下血液生理性能指标变化及红细胞微观形态进行观测分析,得出红细胞破碎的临界撞击速度;结合所设计的螺旋轴流血泵及螺旋混流血泵,应用多相悬浮体CFD仿真技术,对血泵中的速度场进行仿真分析。研究结果表明:当垂直撞击速度达到6m/s以上时,红细胞有可能发生破裂而导致溶血;所设计的螺旋混流血泵中血液由于红细胞撞击破碎而导致的溶血情况并不严重,其血液撞击损伤程度比螺旋轴流血泵的撞击损伤程度低。
The impacting injure principle of blood in the high-speed spiral blood pump was researched using the theory of hernorheology and stress wave. The fragmentation process and conditions of impacting between red blood cell and solid wall were analyzed. Through the observation analysis on the blood living performance and red blood cell micro shapes at several impacting speeds, the critical impact speed on the red blood cell fragmentation was obtained by blood impacting experiment. Combining the designed spiral axial blood pump and spiral mixed blood pump, the speed field of blood pump Were simulated and analyzed using the multiphase suspend body CFD simulation technology. The research results indicate that red blood cell may be broken to lead hemolysis if the perpendicular impact speed is larger than 6 m/s. The hemolysis status caused by red blood cell impact fragmentation is not severe in the designed spiral mixed blood pump. The injure degree of blood impacting is lower than that of spiral axial blood pump.
出处
《中南大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2008年第1期135-142,共8页
Journal of Central South University:Science and Technology
基金
国家自然科学基金资助项目(50775223)
湖南省自然科学基金资助项目(02JJY2080)
关键词
螺旋血泵
撞击
溶血
仿真
spiral blood pump
impacting
hemolysis
simulation
