摘要
化疗药物的耐药较大程度地限制了大肠癌化疗的效果,其中约90%的转移性病例治疗失败可以归因于药物耐药。即使在辅助化疗中,耐药性微转移灶的存在也可能降低化疗的疗效。目前的研究表明,许多因素可以影响化疗药物的敏感性,包括药物的药代动力学、药物的激活或失活、药物作用靶点的变化、(药物诱导的DNA损伤修复、细胞凋亡的逃逸等。本文试从药物代谢、药物靶点、DNA损伤修复及细胞凋亡等方面叙述大肠癌对常规化疗药物的耐药机制,并对新的靶向药物可能的耐药机制作一简要介绍。
Resistance to chemotherapy greatly limits the effectiveness of current therapies for colorectal cancer. Drug resistance may cause treatment failure in over 90% of patients with metastatic cancer, while drug resistant micrometastic tumour cells may also decrease the impact of adjuvant chemotherapy treatment. Factors that affect drug sensitivity include the pharmacokinetic profile of the drug, drug activation and inactivation, alterations in the drug target, processing of drug-induced damage, and evasion of apoptosis. In this review, we describe the potential molecular mechanisms of drug resistance that may be relevant to colorectal cancer.
出处
《癌症进展》
2008年第1期77-82,共6页
Oncology Progress
关键词
大肠癌
化学治疗
耐药性
colorectal cancer chemotherapy drug resistance
