摘要
目的:评价非甾体抗炎药氯诺昔康用于肝癌患者术后静脉自控性镇痛(PCIA)的效应。方法:初选80例进行手术治疗的肝癌患者,随机分为4组。单纯氯诺昔康组(组Ⅰ);小剂量氯诺昔康复合小剂量芬太尼组(组Ⅱ);大剂量氯诺昔康复合小剂量芬太尼组(组Ⅲ);大剂量芬太尼组(组Ⅳ)。评价镇痛效果和副作用的发生率。结果:共有64例肝癌患者在手术后接受了患者自控性静脉镇痛(PCIA)。组Ⅰ在进行了4例后因全部镇痛效果不佳而取消。组Ⅱ、组Ⅲ、和组Ⅳ三组间的镇痛效果无统计学差异(P>0.05),但组Ⅳ的副作用发生率明显高于其余两组(P<0.05)。结论:氯诺昔康不能单独用于术后重度疼痛的镇痛治疗;与芬太尼复合使用,可以在减少芬太尼用量的同时达到相同的镇痛效果,并降低副作用的发生率。
Objective：To assess the efficacy of lornoxicam for patient controlled intravenous analgesia（PCIA） in postoperative patients of liver cancer.Methods：80 patients of liver cancer undergoing surgery therapy were randomly divided into 4 groups.Lornoxicam（group Ⅰ）;Low dose of lornoxicam combined with low dose of fentanyl（group Ⅱ）;High dose of lornoxicam combined with low dose of fentanyl（group Ⅲ）;high dose of fentanyl（group Ⅳ）.The analgesic efficacy and side effects were assessed.Results：There were 64 patients received PCIA.Only 4 patients in group Ⅰ received PCIA and none of them were satisfied with the analgesic efficacy.There was no significant difference in the analgesic efficacy among the other three groups.But there were fewer side effects in groups Ⅱ and Ⅲ than those in the group Ⅳ.Conclusions：Lornoxicam should not be used alone for PCIA in postoperative patients of liver cancer.It was combined with low dose of fentanyl that the dose of fentanyl was decreased and the side effects were also reduced.
出处
《中国疼痛医学杂志》
CAS
CSCD
北大核心
2008年第1期12-16,共5页
Chinese Journal of Pain Medicine
关键词
消炎药
病人静脉自控镇痛
氯诺昔康
芬太尼
Anti-inflammatory agents
Patient controlled in travenous analgesia
Lornoxican
Fentanyl
