摘要
本文报道了新城鸡瘟病毒(NDV-L)感染小鼠腹腔巨噬细胞(PEMΦ)后,可诱TNF-α其因的表达;将NDV-L激活的PEMΦ静脉输入荷B16黑色素瘤小鼠具有明显的抑制其肺转移的作用.
The activating effect of NDV-L on murine PEMψ in vitro and the anti-metastatic effect of NDV-L-PEMψ in vitro against B16 melonoma were investigated. The results showed that NDV-L could not only activate murine PEMψ morphologically , but also enhance the TNF-α gene expression. If the activated NDV-L PEMψ were adoptively transferred in the B16 melanoma bearing mice, significant inhibiting effect against pulmonary metastases could be exhibited.
出处
《中国肿瘤生物治疗杂志》
CAS
CSCD
1997年第2期121-124,共4页
Chinese Journal of Cancer Biotherapy
基金
国家自然基金(39300156)资助
