摘要
目的探讨联合检测血清肿瘤标记物在晚期肺癌临床诊断及预后中的意义。方法采用电化学发光法检测89例晚期肺癌病人血清CEA、NSE、CYFRA21-1的水平。结果CEA、NSE、CYFRA21-1分别在腺癌、小细胞肺癌及鳞癌中呈高表达,其阳性率分别为77.78%、90.9%、80.95%,有统计学意义;CEA在Ⅲ、Ⅳ期肺癌中阳性率分别为44.11%、73.08%,有差异性。结论三项肿瘤标记物联合检测晚期肺癌可提高诊断的灵敏度和准确性,并对肺癌的分型有一定的参考价值。而对于疗效及预后的判断可仅对某一阳性标记物进行长期动态监测。
Objective To explore the significance of combined determination of serum tumor markers levels in the diagnosis and prognosis of advanced lung cancer. Methods The method of electrochemiluminescence was used to examine the combined determination of serum levels of CEA, NSE and CYFRA21 - 1 in 89 advanced lung cancer patients. Results The levels of CEA, NSE and CYFRA21 - 1 showed high expressions in adenocarcinoma, small cell lung cancer and squamous cell carcinoma patients, and the positive rates were 77.78%, 90. 9%, 80. 95% respectively, which had statistical significance. The positivc rates of CEA in stage III and stage IV lung cancer were 44. 11% and 73.08%, which are different. Conclusions The combined determination of serum tumor markers levels can increase the sensitivity and accuracy in lung cancer diagnosis, and have some reference value to this type of lung cancer. Only one of the positive markers can be a long - term dynamic monitoring for the therapy and prognosis of detection.
出处
《辽宁医学院学报》
CAS
2007年第6期46-48,共3页
Journal of Liaoning Medical University (LNMU) Bimonthly
