摘要
目的分析多囊卵巢综合征（PCOS）患者中非酒精性脂肪性肝病（NAFLD）的发病情况。方法选择PCOS患者60例为PCOS组、非PCOS患者60例为对照组，比较两组患者NAFLD的发病情况。结果PCOS组丙氨酸转氨酶（ALT）水平、空腹胰岛素水平和稳态模型胰岛素抵抗指数（HOMA-IR）分别为（29±15）U／L、（19±12）mU／L和0．47±0、29，均显著高于对照组[分别为（15±13）U／L、（11±8）mU／L和0．31±0．21]，差异均有统计学意义（P〈0．05）。PCOS组胰岛素抵抗、NAFLD的发生率分别为63％（38／60）和42％（25／60），与对照组的35％（21／60）和20％（12／60）比较，差异有统计学意义（P〈0．05）。PCOS组ALT异常的发生率为40％（24／60），对照组为3％（2／60），两者比较，差异有统计学意义（P〈0．01）。PCOS组伴有NAFLD患者与不伴NAFLD患者比较，体重指数显著增高，差异有统计学意义（P〈0．01）；腰围臀围比值、ALT、C反应蛋白、空腹胰岛素、口服葡萄糖耐量试验2h后胰岛素水平和HOMA-IR也显著升高，差异也有统计学意义（P〈0．05）。结论PCOS患者中NAFLD患病率升高，提示了两种疾病在临床上的相关性及对PCOS患者进行肝脏相关检查的必要性。
Objective To explore the prevalence of nonalcoholic fatty liver disease （NAFLD） in patients with polycystic ovary syndrome （PCOS）. Methods A case-control study employing 60 nonpregnant patients with PCOS and 60 non-pregnant patients without PCOS as control was conducted to compare the prevalence of NAFLD. Results The aminotransferase （ ALT）, fasting insulin and homeostasis model assessment of insulin resistance （HOMA-IR） levels were （29 ± 15 ） U/L, （ 19 ± 12） mU/L and 0. 47 ± 0. 29 in PCOS group, which were significantly higher （ P 〈 0. 05 ） than corresponding parameters in control group [（15 ± 13）U/L,（11 ± 8）mU/L and 0.31 ±0.21） ]. The occurrence of insulin resistance and NAFLD was 63% （ 38/60 ） and 42% （ 25/60 ）, higher than those in control group [ 35% （21/60 ） and 20% （12/60） ,P 〈 0. 05 ]. The increment of ALT was 40% （24/60） in PCOS group, higher than that of 3% （2/60） in control group （P 〈 0. 01 ）. Compared with patients without NAFLD, patients with NAFLD had significantly increased body mass index （P 〈 0. 01 ）, waist-hip ratio, ALT, C-reaction protein, fasting insulin, insulin and HOMA-IR levels 2 hours after oral glucose tolerance test （ P 〈 0. 05 ）. Conclusion The increased prevalence of NAFLD in PCOS patients suggests an association between these two conditions and the necessity of hepatic screening among PCOS patients for potential NAFLD.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2008年第2期98-101,共4页
Chinese Journal of Obstetrics and Gynecology
关键词
多囊卵巢综合征
脂肪肝
胰岛素抵抗
Polycystic ovary syndrome
Fatty liver
Insulin resistance
