摘要
目的探讨胰岛素抵抗(IR)与冠状动脉病变及微量白蛋白尿(MAU)之间的关系。方法连续收集经冠状动脉造影证实至少有1支血管狭窄≥50%的123例患者作为研究对象,均行口服葡萄糖耐量(OGTT)试验及MAU、胰岛素水平测定。以内环境稳定评估模型(HOMA)值作为评价IR程度指标,对MAU及冠状动脉病变程度行相关分析。结果随着IR程度的增高,MAU水平逐渐增高,冠状动脉病变程度逐渐增高。IR与MAU及冠状动脉病变程度具有明显相关性。结论IR和动脉粥样硬化相关,在冠心病的预防和治疗中要重视IR。
Objective To investigate the relationship of insulin resistance （IR） to coronary lesion and microalbuminuria. Methods One hundred and thirteen consective patients with coronary heart disease （CHD） confirmed by angiography were included. Each patient received oral glucose tolerance test （OGTT） and plasma insulin and urine albumin level were measured. Value of homeostasis model assessment （HOMA） was adopted as the IR index. The relationship of IR to coronary lesion and micro-albuminuria was studied by correlation analysis. Results micro-albuminuria and coronary lesion aggravated gradually with the increase of the IR. IR was significantly correlated with the severity of coronary lesion and micro-albuminuria. Conclusions IR may be an etiologic mechanism for coronary atherosclerosis, and it should be reduced to in the prevention and treatment of CHD.
出处
《中国心血管杂志》
2008年第1期21-23,共3页
Chinese Journal of Cardiovascular Medicine
