摘要
目的分析膀胱鳞状细胞癌(SCC)的临床特点,提高对膀胱鳞状细胞癌的认识及诊治水平。方法回顾性分析我院自1996年1月至2007年5月收治的13例该病患者的临床资料,结合国内外文献进行分析讨论。结果根治性膀胱全切膀胱替代尿流改道术7例,膀胱部分切除术4例,经尿道膀胱肿瘤电切术(TURBT)2例;1例膀胱憩室切除并输尿管再植。6例术后予以膀胱内生理盐水加OK-4325KE灌注治疗。1例术后2个月出现局部复发并盆腔广泛转移死亡;4例膀胱部分切除、1例膀胱全切除及另1例TURBT患者于术后9个月出现全身转移死亡;2例于术后12个月死于高血压心脏病;3例于术后18个月出现复发转移死亡;1例病理报告为高分化角化型鳞状细胞癌患者存活24个月,目前继续随访中。结论膀胱SCC往往呈浸润性生长,恶性程度较高,预后差。根治性膀胱全切术为其最佳治疗方法,膀胱肿瘤切除术后沙培林(OK-432)灌注治疗可适当延长其生存期,值得临床进一步研究。
Objective To investigate the feature and to improve diagnostic and therapeutic standards of squamous cell carcinoma（SCC） of urinary bladder. Methods Clinical data of 13 cases of SCC of urinary bladder were analysed retrospectively and discussed with related literature. Results Seven cases underwent radical cystectomy and urinary diversion, of whom, only 1 survived now. Four cases received partial cystectomy and 2 cases received transurethral resection of bladder tumor （TURBT）. All of them received bladder instillation with OK-432 and still had recurrence within 18 months after operation. Conclusion SCC had the features of strong infiltration ,high malignancy and poor prognosis. The first choice of treatment is red- ical cystectomy and urinary diversion. Bladder instillation with OK-432 can give a good chance to prolong the life span after partial cystectomy or TURBT.
出处
《中国肿瘤临床与康复》
2008年第1期76-78,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
膀胱肿瘤/治疗学
鳞状细胞癌
Bladder neoplasms/treatment
Squamous cell carcinoma
