摘要
目的:探讨不同组织学类型膀胱癌组织中HER2蛋白的表达及意义。方法:采用免疫组化法检测73例不同组织学类型的膀胱癌组织中HER2蛋白的表达水平及其与临床分期、病理分级之间的关系。结果:HER2蛋白在膀胱鳞状细胞癌(鳞癌)、腺癌和尿路上皮细胞癌组织的阳性表达率分别为88.9%(16/18)、88.2%(15/17)和57.9%(22/38),差异有统计学意义(P=0.016),鳞癌和腺癌两者之间的表达差异无统计学意义(P>0.999),尿路上皮细胞癌组织中HER2的阳性表达率低于鳞癌和腺癌(χ2=8.620,P=0.003);膀胱癌组织中HER2蛋白的表达与患者的性别、年龄、肿瘤大小无关(P>0.05),而与肿瘤TNM分期、分化程度及淋巴结转移有关(χ2=7.980,11.559,11.934,P<0.05)。结论:HER2蛋白可以作为鉴别不同组织学类型膀胱癌的潜在指标,并与膀胱癌的增殖、浸润、转移密切相关。
Aim：To explore the expression and the significance of HER 2 protein in different histological types of blad-der cancers .Methods：The immunohistochemistry SP method was used to detect the expression of HER 2 protein in 73 ca-ses of different histological types of bladder cancers .Results： The positive expression rate of HER2 protein was 88.9%（16/18） in squamous cell cancer ,88.2%（15/17） in adenocarcinoma and 57.9%（22/38） in urothelial cell carcinoma , there were statistical differences（P=0.016）, there was no significant difference between squamous cell carcinoma and ad-enocarcinoma （P＆gt;0.999）.The positive expression rate of HER2 in urothelial cell carcinoma were lower than those in squamous cell carcinoma and adenocarcinoma （χ2 =8.620,P=0.003）.The expression of HER2 protein in bladder cancer was not correlated with patient＆#39;s gender, age or tumor size（P＆gt;0.05）,but correlated with the tumor TNM stage ,differentia-tion degree and lymph node metastasis （χ2 =7.980,11.559,11.934,P＆lt;0.05）.Conclusion： HER2 protein can be used as potential indicators identifing different histological types of bladder cancer and closely related with bladder cancer ＆#39;s pro-liferation, invasion and metastasis .
出处
《郑州大学学报（医学版）》
CAS
北大核心
2014年第1期96-98,共3页
Journal of Zhengzhou University(Medical Sciences)
