摘要
目的观察外周性原始性神经外胚层肿瘤(pPNET)皮下埋植式动脉化疗的疗效。方法外周性原始神经外胚层肿瘤8例,男6例,女2例;中位年龄12.4岁。经皮下埋植式给药装置行阿霉素、顺铂联合咖啡因导向性灌注3～4次,化疗后进行手术或放射综合治疗。结果化疗后疼痛完全缓解;肿瘤病灶CR3例,PR5例,有效率100%。平均生存28.4个月,生存率37.5%。结论pPNET是一种极度恶性的小圆细胞肿瘤,皮下埋植式动脉化疗是一种有效的化疗方法,但还要辅以手术和放射治疗。
Objective To observe the clinical results of intra-arterial chemotherapy by subcutaneous implantable delivery system in the treatment of perpheral primitive neuroectodermal tumours （pPNETs）. Methods Eight cases of pPNET（male 6 cases, female 2 cases, average age was 12.4 years ） were treated with cisplatin, adriamycin and caffeine targeting infusion by subcutaneous implantable intra-arterial drug delivery system for 3-4 times. Operation or radiation was given after chemotherapy. Results Total effective rate （CR） of relieving pain was 100%. CR of tumor was found in 3 cases,PR 5 cases,RR 100%. Average survival period was 28.4 months, rate of survival was 37.5%. Conclusion pPNET is a kind of malignant small round cell tumor with rapid aggressive clinical course. Intra-arterial chemotherapy by subcutaneous implantable delivery system is an effective treatment method. Operation or radiation is also necessary for auxiliary treatment.
出处
《中国肿瘤临床与康复》
2008年第1期38-41,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
