摘要
目的:研究玄归止痛滴丸对气血淤滞所致疼痛的药效学。方法:取玄归止痛滴丸用新沸过的蒸馏水配置3个剂量组(相当于原生药0.25、0.5、1g.kg-1),灌胃给药,比较在活血、止痛、抗炎、常压耐缺氧功能及改善血淤模型的血液流变学指标方面,玄归止痛滴丸对模型动物的影响。结果:玄归止痛滴丸对模型小鼠有显著的镇痛、抗炎、抗凝血及常压下耐缺氧作用;玄归止痛滴丸对寒凝血淤证模型兔血液的黏、浓、凝、聚状态也有显著改善。结论:玄归止痛滴丸有显著的镇痛作用和一定的活血作用。
OBJECTIVE： To study the pharmacodynamics of Xuanguizhitong drop pill in the treatment of pain caused by Qi- blood Stasis. METHODS： Xuanguizhitong drop pill were prepared into 3 different doses （0.25,0.5, and 1 g · kg^-1） with new distilled water. The effects of Xuanguizhitong drop pill at different dose in promoting blood flow, analgesia, anti - inflammatory effect, the ability of anoxia- tolerance at ordinary pressure, and improving the hemorheology indexes in blood stasis model animals were compared. RESULTS： Xuanguizhitong drop pill were remarkable in analgesic, anti- inflammatory and anticoagulant effects and anoxia- tolerance ability at ordinary pressure.The hyperviscosity, thickness, coagulation and accumulation of blood caused by ＂cold accumulation＂ in the blood stasis syndrome model rabbits were also improved significantly by Xuanguizhitong drop pill.CONCLUSION： Xuanguizhitong drop pill has remarkable analgesic effect and can promote blood flow to a certain extent.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第6期415-417,共3页
China Pharmacy
关键词
玄归止痛滴丸
镇痛
抗炎
抗凝血
耐缺氧
Xuanguizhitong drop pill
Analgesia
Anti - inflammatory
Anticoagulation
Oxy- tolerance
