摘要
目的:研究银屑灵片止痒的作用。方法:用低分子右旋糖酐-40诱导内源性组胺释放,制备瘙痒模型,观察给予低分子右旋糖酐-40后至小鼠首次搔抓所用的时间(潜伏时间)和30min内的搔抓次数。皮下注射磷酸组胺同时尾静脉注射伊文思蓝生理盐水染色,30min后剪下腹部蓝染皮肤测量蓝斑面积。结果:银屑灵片高、中、低剂量组较空白对照组潜伏时间显著延长,搔抓次数亦显著减少,其中银屑灵片高、中剂量组与扑尔敏未见差异;银屑灵片高剂量组较空白对照组小鼠腹部蓝染的风团面积显著减少,与扑尔敏未见差异;银屑灵片高剂量组的潜伏时间、搔抓次数、风团面积,结果均优于迪银片。结论:银屑灵片具有较好的止痒作用。
OBJECTIVE： To study the antipruritic effect of Yinxieling tablet.METHODS： To pruritus model was made using dextran - 40 to induce endogenous histamine release. The latent time for the onset of scratching after giving dextran - 40 in Jimpy mice and the frequency of scratching within 30 min were observed. Histamine phosphate was given by endermic injection meanwhile evans blue physiologic saline was injected to caudal vein for staining in Jimpy mice, 30 min later, blue - stain skin was cut for the measurement of size of evans blue spots. RESULTS： The latent time was significantly longer and the scratching times were significantly less in Yinxieling tablet groups（high,middle, and low doses） than in blank group, however, no significant difference was noted between Yinxieling tablet subgroups （high and middle doses） and Chlorphenamine group. The wheal area of blue - stain skin in mice＇ s hypogastric zone was significantly less in high dose Yinxieling tablet group than in blank group, but the difference between high dose Yinxieling tablet group and Chlorphenamine group was not significant. The high dose Yinxieling tablet group was superior to Diyin tablet in latent time, frequency of scratching and wheal area. CONCLUSION： Yinxieling tablet have satisfactory antipruritic effect.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第6期409-411,共3页
China Pharmacy
基金
广东省自然科学基金资助项目(04010055)
关键词
银屑灵片
止痒作用
实验研究
Yinxieling tablet
Antipruritic effect
Empirical study
