摘要
本研究采用大鼠脑缺血再灌注模型，观察灯盏花素对脑缺血再灌注损伤的保护作用。结果表明，灯盏花素能不同程度地降低脑含水量和ＭＤＡ含量，提高ＳＯＤ、ＣＡＴ和ＧＳＨ－Ｐｘ活性，保护Ｎａ＋，Ｋ＋－ＡＴＰ酶活性。提示灯盏花素可通过保护脑组织抗氧化酶的活性，抑制脂质过氧化反应，减轻自由基对脑组织的损害对缺血再灌注脑组织的保护作用。
The effects of Breviscapine,a active ingredient isolated from Erigeron breviscapus (Vant) Hand. mazz, on cerebral ischemia reperfusion injury in rats were investigated. To certain extent in the brain,breviscapine decreased the contents of water and malondialdehyde (MDA), elevated the activities of superoxide dismutase ( SOD ), as well as glutathione peroxidase ( GSH Px ) and catalase ( CAT ) , and suspressed the reduction of Na +,K + ATPase activity. It is suggested that breviscapine can protect against cerebral ischemia reperfusion injury by enhancing the activity of anti oxidative enzymes, inhibiting lipid peroxidation subsequently and attenuating free radicals mediated brain damage.
出处
《广东药学院学报》
CAS
1997年第2期90-93,共4页
Academic Journal of Guangdong College of Pharmacy
关键词
大鼠
脑缺血
再灌注损伤
保护作用
灯盏花素
breviscapine
cerebral ischemia reperfusion
brain edema
lipid peroxidation
Na +,K + ATPase
