摘要
目的 研究中国人Barrett食管（Barrett’s esophagus，BE）的临床特点。方法以“Barrett食管”为检索词，电脑检索1989年～2007年国内公开发表的中文文献，以“Barrett esophagus”和“China”为检索词，电脑在MEDLINE上检索1989年-2007年公开发表有关中国Barrett食管临床研究英文文献，统一纳入标准和排除标准，所得资料进行荟萃分析。结果共41项研究中的4132例BE患者进入本研究：①BE的内镜检出率为2．39％，男女比为2．08：1，平均发病年龄为53．27岁，有典型胃食管反流病（GERD）症状的51．00％；②内镜下形状以岛状居多，为56．81％；特殊肠化生型为36．58％；舌型BE的特殊肠化生检出率较全周型、岛状均显著增高（均P〈0．001）；长段Barrett食管的特殊肠化生型检出率高于短段Barrett食管（P〈0．001）；③492例BE患者平均2年随访，癌变发生率为0．61％。结论我国人内镜BE检出率低于西方人，平均发病年龄低于西方国家报道，癌变发生率与国外报道接近，男性多发、临床症状、特殊肠化生型检出率等与国外报道一致。
Objective To investigate the endoscopic and clinico-pathological characteristics in patients with Barrett esophagus in China. Methods Using the terms of＂ Barrett＇s esophagus＂ and＂ Barrett＇s esophagus, china＂ as key words, literatures published in Chinese and English journals were searched by Chinses data banks and MEDLINE from 1989 to 2007. An analysis was carried out with the standard inclusion and exclusion criteria. Results Four thousand one hundred and thirty two cases were included in this study. ① BE was found in 2.39% of patients undergoing endoscopy for various symptoms of upper gastrointestinal tract diseases. Male and female were in the ratio of 2.08：1 and the average age of onset was 53.27 years. And 51% of patients with BE occurred ease （GERD）. ② The island-type Barrett esophagus was predominant, intestinal metaplasia was 36.58% ,but the special intestinal metaplasia specific symptoms for gastroesophageal reflux disabout 56.81%. The incidence of BE with special was more common in tongue-type BE than that in island-type and circumferential-type （both P 〈 0. 001 ）, and it was more observed in long segment BE than that in short segment esophagus（P 〈 0. 001 ）. ③ The mean length of follow-up was 2 years in 492 patiens. The incidence of adenocarcinoma was 0.61%. Conclusion In China,the endoscopic incidence of Barrett esophagus is lower than that in Western countries, but the average age of onset is younger. There is an approximate value of the incidence of BE developing adenocarcinoma between Chinese and Westerners. Similarily to reports from Western countries,BE is more frequent in male than in female, about half patients have no specific symptoms of GERD,the tongue-type and the long segment Barrett esophagus are apt to special intestinal metaplasia.
出处
《胃肠病学和肝病学杂志》
CAS
2008年第2期102-105,共4页
Chinese Journal of Gastroenterology and Hepatology
关键词
BARRETT食管
内镜特征
临床病理特征
随访
Barrett esophagus
Endoscopic characteristics
Clinico-pathological characteristics
Follow-up
