摘要
以丙烯酸甲酯或辛酯和二乙烯苯为原料，在溶液中用游离基聚合法制备了一系列含酯基包覆聚合物反相液相色谱柱填料．用傅立叶红外光谱、电子显微镜和元素分析鉴定了聚合物层，并评价了诸如硅羟基、柱压降、柱效和峰对称性等特性．该类填料适合于含氨基和羟基化合物的分离，作为应用实例，对洛伐他汀（Lovastatin）的分析展示其优良的色谱性能。
A series of ester-containing polymer encapsulated packing material for reversedphase high performance liquid chromatography was prepared by radical polymerization ofmethyl or octyl acrylate and divinylbenzene with vinyl-bonded silica in solution. The polymerlayer was characterized by FTIR, SEM and elemental analysis. Some characteristics such asresidual silanols, column pressure, column efficiency and peak asymmetry were evaluated.The polymer encapsulated packing materials are inorganic packings with organic coatings,thus combining the favorable mechanical properties of silica nuclei with the favorablechemical stability of polymer coatings. The plots of lgk' of solute against methanol content of amobile phase using the packing material. In the case of aniline, benzene, and o-nitrophenol,the plots have a linearity similar to those of reversed phase packings. These packings weresuitable for separation of amino- and hydroxyl groups containing compounds because of thestability and the absence of acidic silanol groups. At the same time, they will play animportant role in rapid separations of complex mixtures because the mass transfer to the stationaryphase is fast. Its superior performance for the analysis of Lovastatin is demonstrated asapplication example.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1997年第9期1479-1483,共5页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
南开大学吸附分离功能高分子材料国家重点实验室资助
关键词
液相色谱
包覆聚合物
填料
丙烯酸酯
二乙烯苯
Liquid chromatography, Polymer encapsulated packings, Column packing,Acrylate-divinylbenzene copolymer
