摘要
以邻苯二胺和糠醛为原料,硅胶吸附的水合三氯化铈-碘化钠(CeCl3.7H2O-NaI)催化合成苯并咪唑,研究了原料配比、反应温度和反应时间等工艺条件。结果表明,较佳工艺条件为:反应物料配比n(邻苯二胺)∶n(糠醛)=1.0∶2.0,反应温度80℃,反应时间2.5 h。在此条件下,2-(2-呋喃基)苯并咪唑收率达90%以上,纯度达92%。催化剂(SiO2-Supported CeCl3.7H2O-NaI)重复利用4次后,产物收率仍在80%以上,并可避免使用有机溶剂。
Using O-phenylendiamine and furfural as the starting material,Fuberidazole were prepared with SiO2-supported CeCl3·7H2O-NaI as catalyst.The effects of the reaction conditions on the reaction results such as molar ratio,reaction temperature and reaction time were examined.The optimum conditions are as follows：n（O-phenylendiamine） ∶ n（furfural） = 1.0 ∶ 2.0,reaction temperature 80 ℃,reaction time 2.5 h.Under these conditions the yield of 2-benzoylpyrrole was over 90%,purity was up to 92%.SiO2-Supported CeCl3·7H2O-NaI can be duplicatedly used,the production rate can still reach 80% after using four times,the process can react without solvents.
出处
《应用化工》
CAS
CSCD
2013年第8期1438-1440,共3页
Applied Chemical Industry
基金
2011年度省第二批科技型企业技术创新资金(苏财工贸[2011]118号)
2012年江苏省苏北科技发展计划项目(科技型企业技术创新资金
苏财工贸[2012]98号
BC2012452)
