摘要
目的:观察喜普妙治疗精神分裂症阴性症状疗效和不良反应。方法:采用随机分组法,将110例精神分裂症分为研究组(利培酮+喜普妙)和对照组(利培酮),在治疗前和治疗后第4、8、12周末以阳性症状和阴性症状量表(PANSS)总分减分率,阴性因子分减分率和不良反应量表(TESS)评定疗效和不良反应。结果:治疗12周末研究组PANSS总分减分率(54.29±26.64)%,阴性因子分减分率(50.55±25.79)%,对照组分别为(34.69±19.77)%、(30.08±18.37)%,差异有统计学意义(P<0.01)。研究组阴性因子各症状分在12周末均低于对照组(P<0.01)。结论:喜普妙治疗精神分裂症安全有效,协同利培酮治疗精神分裂症可增加疗效。
Objective ： To observe the efficacy and side effects of citalopram in the treatment of negative symptoms in schizophrenia, Methods：110 chronic schizophrenia patients were divided ramdonly into two groups,one group were treated with citalopram combined with risperidone and the other group were treated with risperdone combined with placebo. Effects and side effects were assessed with the Positive and Negative Syndrome Scale（PANSS）and Treatment Emergent Symptoms Scale（TESS）respectively before and after treatment 4、8、12 week. Results; The reduction on PANSS score and on negative symptom scale at week 12 were（54.29±26.64） % and（50.55±25.79）% in citalopram group,which were more than that in placebo combined group（ 34.69±19.77 ）% and（ 30.08±18.37）% P〈0.001 ）. Conclusions： Conclusion： It is suggested that citalopram combination with typical antipsychotics is effective and safe in the negative symptom of schizophrenia patients.
出处
《中国冶金工业医学杂志》
2008年第1期11-13,共3页
Chinese Medical Journal of Metallurgical industry
关键词
精神分裂症
利培酮
喜普妙
阴性症状
Schizophrenia
Risperidone
Negative symptom
Citalopram
