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苯接触标志物尿中苯巯基尿酸的分析与评价 被引量：3

Analysis and evaluation of S-phenylmercapturic acid as a biomarker for benzene exposure
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摘要 尿中苯巯基尿酸(SPMA)与苯接触存在良好相关性,是低浓度苯接触特异和敏感的生物标志物。SPMA可用高效液相色谱法(HPLC)、液质联谱(LC/MS)、气质联谱(GC/MS)和酶联免疫吸附试验(ELISA)等方法检测。本文详细介绍了国外检测尿SPMA的方法,评价了尿SPMA作为职业苯接触生物标志物的有效性和应用。 Since urinary S-phenylmercapturic acid concentration could be well related to benzene exposure, it could be a sensitive and specific biomarker of low-level benzene exposure. SPMA may be determined by HPLC, LC/MS, GC/MS and ELISA methods. The abroad methods of determination of urinary SPMA were reviewed in detail in recently years and the validation and application of urinary SPMA as a biomarker for occupation benzene exposure were evaluated.
作者 罗巧 朱长才 宋世震
机构地区 武汉科技大学医学院劳动卫生教研室
出处 《卫生研究》 CAS CSCD 北大核心 2008年第1期106-108,共3页 Journal of Hygiene Research
关键词 苯 尿中苯巯基尿酸 生物监测 职业中毒 benzene, urinary S-phenylmercapturic acid, biological monitoring, occupational poisoning
分类号 R598.120.1 [医药卫生—内科学] R135.12 [医药卫生—劳动卫生]
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参考文献14

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二级参考文献15

  • 1吴宜群,唐瑾,程玉琪,李春玲,李晓华,曲宁,虞爱如,祖静华.人尿中酚、粘糠酸、苯巯基尿酸的生物监测[J].中华劳动卫生职业病杂志,1997,15(3):134-137. 被引量：8
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二级引证文献19

卫生研究
2008年 第1期

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