摘要
目的检测老年糖尿病患者胰岛细胞自身抗体的水平,并对其影响胰岛β细胞功能的相关因素进行分析。方法对142例老年糖尿病患者进行血清谷氨酸脱羧酶抗体（GAD-Ab）、胰岛细胞抗体（ICA）和胰岛素自身抗体（IAA）检测,对抗体阳性组与阴性组临床及生化指标进行比较。结果GAINAb阳性组空腹C肽水平（3.38±1.98）μg/L,较阴性组（4.13±2.32）μg/L明显降低（P〈0.05）;2种抗体同时阳性组（3.05±2.88）μg/L较1种抗体阳性组（3.97±2.68）μg/L降低。ICA、IAA阳性组空腹C肽水平与阴性组比较,差异无统计学意义。老年糖尿病患者空腹C肽水平与三酰甘油水平呈正相关,与GAD-Ab水平呈负相关。GAD-Ab阳性组与阴性组胰岛素抵抗指数差异无统计学意义。GAD-Ab、ICA、IAA阳性组及阴性组对年龄、性别、是否接受胰岛素治疗、空腹血糖、餐后2 h血糖、糖化血红蛋白、空腹胰岛素、血脂及尿蛋白/肌酐水平进行比较,差异均无统计学意义。结论胰岛细胞自身抗体检测对老年人糖尿病的诊断分型具有重要意义。
Objective To investigate the levels of islet autoimmune antibodies in elderly diabetic patients.Methods One hundred and forty-two elderly patients with diabetes were enrolled in the study,and levels of glutamic acid decarboxylase antibodies（GAD-Ab）,islet cell antibodies（ICA）, insulin autoantibodies（IAA）were detected.All the patients were divided into antibody positive and negative groups.Blood biochemical indicators and clinical characteristics were compared between these groups.Results Fasting C peptide level was lower in GAD-Ab positive group[（3.38±1.98）μg/L] than in GAD-Ab negative group[（4.13±2.32）μg/L]（P〈0.05）.Fasting C peptide level was lower in any 2 antibodies positive group[（3.05±2.88）μg/L] than in only one antibody positive group [（3.97±2.68）μg/L].There was a positive correlation between triglyceride（TG）level and fasting C peptide level in elderly diabetes patients.A negative correlation was found between GAD-Ab level and fasting C peptide level.There was no difference in insulin resistance index between GAD-Ab positive group and negative group.There were no differences in age,sex,percentage of treatment with insuline,fasting plasma glucose,PBG,HbAlc,fasting insulin,TG,total cholesterol and urine Alb/ Cr levels between the islet autoantibodies（GAD-Ab,ICA,IAA）positive and negative groups.There was no difference in fasting C peptide level between ICA,IAA positive and negative groups. Conclusions Screening of islet autoimmune antibodies is important in diagnosis and etiological classification for elderly diabetic patients.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2008年第1期42-44,共3页
Chinese Journal of Geriatrics
关键词
糖尿病
2型
胰岛素抗体
胰岛素抗药性
自身抗体
Diabetes mellitus,type 2
Insulin antibodies
Insulin resistance
Autoantibodies
