摘要
目的:研究几种氨基酸失衡液对荷瘤宿主肝癌抑制的影响。方法:以荷肝癌H22ICR小鼠为研究对象,给予全胃肠内营养液12d,根据营养液中氨基酸组成的不同分为:A组(平衡氨基酸组),B组(富含精氨酸氨基酸失衡组),C组(去缬氨酸氨基酸失衡组),D组(富含亮氨酸氨基酸失衡组),E组(去酪氨酸氨基酸失衡组),F组(去苯丙氨酸氨基酸失衡组),G组(去丝氨酸氨基酸失衡组)。以肿瘤体积、肿瘤质量、肿瘤质量/尸质量、肿瘤细胞坏死率、增殖细胞核抗原(PCNA)指数以及DNA倍性作为观察肝癌抑制的指标。结果:B、C、D、E、F、G与A组比较,肿瘤体积、肿瘤质量、肿瘤质量/尸质量以及PCNA指数差异均有统计学意义(P<0.01),各组肿瘤细胞坏死率、DNA倍性未发现显著性差异(P>0.05)。结论:平衡氨基酸组促进肝癌生长,各氨基酸失衡组对肝癌生长具有一定程度的抑制作用。
Objective： To study the influence of several amino acid imbalance solutions on inhibition of hepatocarcinoma in tumor-beating mice. Methods： Total gastric-intestinal nutrition solutions were given to hepatoma22- bearing mice for 12 days. According to formulas of amino acid composition in nutrition solutions, the hepatoma22-bearing mice were divided into seven different groups,group A （amino acid balance solution）,group B （arginine-enriched amino acid imbalance solution）, group C （valine-depleted amino acid imbalance solution）, group D （leusine -enriched amino acid imbalance solution）,group E （tyrosine-depleted amino acid imbalance solution）,group F （phenylalanine-depleted amino acid imbalance solution） and group G （serine -depleted amino acid imbalance solution）. Indices of hepatocarcinoma inhibition include tumor volume,tumor weight, tumor weight/carcass body weight, necrotic rate of tumor cell, PCNA and DNA ploidy. Results： All tumor inhibition indices were significantly lower in B, C, D, E, F and G groups compared with those in the group A（P 〈 0.01 ） except necrotic rate of tumor cell and DNA ploidy（P 〉 0.05 ）. Conclusion： The amino acid balance solution can stimulate tumor growth, but all amino acid imbalance solutions have inhibition effects on hepatocarcinoma in tumor-beating mice.
出处
《天津医药》
CAS
北大核心
2008年第1期38-40,共3页
Tianjin Medical Journal
基金
天津市卫生局课题(项目编号:05KY15)
关键词
氨基酸类
肝肿瘤
增殖细胞核抗原
小鼠
amino acids liver neoplasms proliferating cell nuolear antigen mice
