摘要
观察了中药咳宁冲剂体内外抗流感病毒作用。体内实验表明咳宁冲剂高（３ｇ／ｋｇ）、低（１．５ｇ／ｋｇ）剂量均能减低滴鼻感染２０ＬＤ５０流感甲型病毒引起的小鼠死亡率、病毒性肺炎小鼠的肺指数和肺组织病毒血凝滴度。与对照组比较，大剂量组差异有显著性（Ｐ＜０．０５）。体外实验表明０．２５％咳宁（无细胞毒浓度）对细胞病变（ＣＰＦ）、血凝滴度（ＨＡ）和红细胞吸附滴度（ＨＤ）无明显影响。
WTBZ〗The effect of Kening (KN) Granule on influenza virus in vivo and in vitro were studied experimentally. The results showed that KN (3 g/kg & 1.5 g/kg) could decrease the mortality of mice infected by nasal drop of 20 LD 50 influenza virus(P< 0.05 ). 0.25 % KN, a maximal uncytotoxic concentration ,has no influence on cytopathic effect, hemagglutination and hemadsorption in vitro. [WT5”HZ〗
出处
《中药新药与临床药理》
CAS
CSCD
1997年第3期144-146,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
中药品
咳宁冲剂
药理学
流感病毒
WTBZ〗@ KeningGranule/pharmacology
influenza viruses/drug effect
influenza viruses/pathogenicity
