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AQP4与中枢神经系统中水平衡关系的研究进展 被引量:4

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摘要 水通道蛋白4(AQP4)是中枢神经系统中最主要的水通道,其功能是调节水平衡,并与脑水肿的形成关系密切。研究表明AQP4基因敲除可显著减少细胞毒性脑水肿模型的液体积聚,相反,血管源性水肿源于一种不依赖AQP的血脑屏障通透性增高机制,导致细胞外液体积聚,AQP4则有助于消除细胞外液体。同时AQP4通过调节水平衡和离子稳态在神经信号和感觉信号传导中也发挥着作用。
出处 《国际神经病学神经外科学杂志》 2007年第6期579-582,共4页 Journal of International Neurology and Neurosurgery
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