摘要
为了研究白介素（ＩＬ）１２、ＩＬ１５和肿瘤坏死因子α（ＴＮＦα）在尖锐湿疣发病机理中的作用，采用双抗体夹心酶扩大敏感性免疫检测（ＥＡＳＩＡ）技术检测了尖锐湿疣患者血清ＩＬ１２、ＩＬ１５及ＴＮＦα的水平。结果发现尖锐湿疣患者ＩＬ１２水平比正常人显著降低（Ｐ＜００５），ＩＬ１５水平虽有降低，但无显著性差异；ＴＮＦα水平则无明显改变，说明由于ＩＬ１２水平低下而导致一系列细胞免疫反应抑制效应，包括在病毒（特异性抗原）早期感染时，不能有效地启动Ｔｈ１型细胞对病毒抗原的应答反应以及增强Ｔ细胞和自然杀伤细胞活性，在尖锐湿疣发病机理中起着重要作用。
In order to study the role of interleukin(IL)12, IL15 and tumor necrosis factor alpha(TNF α) in the pathogenesis of condyloma acuminatum(CA),we used double antibody sandwich ELISA for the quantitative determination of serum IL12,IL15 and TNF α levels in 31,38 and 27 patients with CA respectively. The results showed the serum IL12 level was significantly(P<0 05) lower in CA patients than that of controls. The level of IL15 was also lower in patients than that in normals, but the difference was not significant (P>0 05).The TNF α level in patients was almost the same as the controls.These results indicate that the lower level of IL12 results in inhibitory effects on a series of cell immune responses,being not able to have an effect on T cell and NK cell activation and initiation of Th1-type cell responses at the very early stages of virus infection,which may play an important role in the pathogenesis of CA.
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
1997年第3期172-174,共3页
Chinese Journal of Dermatology
