摘要
为了探讨肠道病毒感染与扩张型心肌病发病的关系，应用聚合酶链反应等方法对２１例患者心肌及血标本进行肠道病毒检测，结果显示９例患者心肌组织中有肠道病毒ＲＮＡ存在，阳性率为４２．９％；１７例外周血标本中，亦有６例阳性；而１７例患者血清中，仅４例有柯萨奇Ｂ组病毒中和抗体存在，表明部分扩张型心肌病患者中确有肠道病毒感染或持续感染，支持肠道病毒感染和（或）持续感染参与部分扩张型心肌病发生及发展过程。
To investigate the role of enteroviral infection in the patho genesis of dilated cardiomyopathy (DCM), we used the nested reverse transcription polymerase chain reaction to detect enteroviral RNA in 21 myocardial specimens and 17 peripheral blood samples from patients with DCM and 21 patients(controls) with cerebral trauma. Enteroviral RNA was detected in 9 of 21 myocardial tissues and 6 of 17 blood samples, whereas all controls myocardial samples were negative. In addition, antibodies of coxsackievirus group B were detected in 4 of the 17 patients with DCM by neutralization test. The present study suggested that DCM might be associated with persistent enteroviral infection.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1997年第6期377-379,共3页
Chinese Journal of Internal Medicine
