摘要
目的探讨不同剂量川芎嗪对体外循环(CPB)所致炎症反应和心肌缺血-再灌注损伤(MIRI)的保护作用。方法60例先天性房间隔或(和)室间隔缺损患者随机分为对照组(A组)、盐酸川芎嗪3mg/kg组(B组)、9mg/kg组(C组)、12mg/kg组(D组)。分别于诱导后(T0)、转机后15min(T1)、停机后2h(T2)、停机后6h(T3)、手术后24h(T4)抽取静脉血测量血清中肿瘤坏死因子(TNF)、心肌肌钙蛋白I(cTnI)的浓度,并观察血流动力学指标。结果TNF的含量B、C、D组T2与A组相比有统计学差异,但是C、D两组的差异更加显著;整体上,C、D两组较A、B两组显著降低。cTnI的含量:A组cTnI的峰值出现在T4,C组T2、T3、T4与T1无统计学差异;C组T4时与A组相比具有显著差异;整体上,C组较A组降低。各组血流动力学指标无差异。结论川芎嗪对体外循环(CPB)所致炎症反应和心肌缺血-再灌注损伤(MIRI)有保护作用,以9mg/kg作用较为显著。
Objective To evaluate the protective effect of ligustrazine in different dosage on inflammatory reaction and myocardial ischemia-reperfusion injury induced by cardiopulmonary bypass（CPB）. Methods Sixty patients with congenital atrial or（and） ventricular septum defect undergoing open heart surgery with CPB were divided into 4 groups at random： group A （control group） ; Ligustrazine groups, receiving Ligustrazine 3 mg/kg（B）, 9 mg/kg（C）, 12 mg/kg（D）, respectively. Tumor necrosis factor（TNF） and cardiac troponin I （cTnI） were measured after induction（T0）, at 15 rain during CPB（T1 ）, at 2 h（T2）and 6 h（T3）after CPB, at 24 h after operation（T4）. All hemodynamic indices of these patients were recorded accordingly. Results TNF concentration was lower in groups B,C,D than in group A at T2 ,and significantly lower in group C,D than in group B. TNF concentration was significantly lower in groups C,D than in groups A,B as a whole. The cTnI concentration peaked at T4 in group A, whereas there was no significant difference between T1 ,T2 ,T3 and T4 in group C. The cTnI concentration had significant difference at T4 between group C and group A. The cTnI concentration was lower in group C than in group A as a whole. All hemodynamics indices had no significant difference among groups A, B, C and D. Gmclusion Ligustrazine has protective effect on inflammatory reaction and myocardial ischemia-reperfusion injury induced by cardiopulmonary bypass（CPB）, and 9 mg/kg ligustrazine is more effective.
出处
《山西医科大学学报》
CAS
2008年第1期70-74,共5页
Journal of Shanxi Medical University
关键词
再灌注损伤
体外循环
川芎嗪
炎症反应
reperfusion injury
cardiopulmonary bypass
ligustrazine
inflammatory reaction
