摘要
目的:对咽乐含片进行处方优选。方法:采用L8(2)7正交试验设计表,以方中7味中药作为7个因素,排列组合得到8组配方;选用小鼠肉芽肿生长抑制、耳肿胀抑制及小鼠酚红祛痰实验结果作为观察指标。结果:从小鼠肉芽肿生长抑制实验结果可以看出,甘草、金银花对结果存在显著影响;从小鼠耳肿胀抑制实验结果可以看出,麦冬、射干、木蝴蝶、甘草、金银花对结果存在显著影响;从小鼠酚红祛痰实验结果可以看出,南沙参、桔梗对结果存在显著影响。说明处方中每一味药对某一药效结果均有影响。结论:原方组方合理,为最佳组合。
OBJECTIVE： To optimize the formula of Yanle buccal tablets. METHODS： 8 different formula were derived from L8（2）^7 orthogonal design table taking 7 Chinese medicines as factors. The main outcome measures were granuloma growth inhibition test, ear swelling inhibition test and phenol red＇ s phlegm eliminating test in mice. RESULTS： The results showed that that Radix et Rhizoma Slycyrrhizae and Flos Lonicerae Japonicae had significant impact on mice＇s granuloma growth inhibition test Result; Radix Ophiopogonis, Rhizome, Belamcandae, Semen Oroxyli, and Flos Lonicerae J aponicae had significant impact on mice＇ s ear swelling inhibition test result; and Radix et Rhizoma Slycyrrhizae and Radix Platycodi had great impact on phenol red＇ s phlegm eliminating test result in mice, suggesting pharmacodynamic action. CONCLUSION： The original formula is that every Chinese medicine （factor） had effect on certain the reasonable and optimum one.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第3期180-182,共3页
China Pharmacy
关键词
正交试验
咽乐含片
处方优选
Orthogonal test
Yanle buccai tablets
Optimization oi iormula
